全文获取类型
收费全文 | 7544篇 |
免费 | 1003篇 |
国内免费 | 1058篇 |
专业分类
化学 | 6502篇 |
晶体学 | 176篇 |
力学 | 138篇 |
综合类 | 105篇 |
数学 | 645篇 |
物理学 | 2039篇 |
出版年
2024年 | 8篇 |
2023年 | 113篇 |
2022年 | 234篇 |
2021年 | 356篇 |
2020年 | 332篇 |
2019年 | 314篇 |
2018年 | 275篇 |
2017年 | 331篇 |
2016年 | 347篇 |
2015年 | 310篇 |
2014年 | 450篇 |
2013年 | 634篇 |
2012年 | 477篇 |
2011年 | 494篇 |
2010年 | 343篇 |
2009年 | 470篇 |
2008年 | 531篇 |
2007年 | 483篇 |
2006年 | 437篇 |
2005年 | 381篇 |
2004年 | 382篇 |
2003年 | 304篇 |
2002年 | 239篇 |
2001年 | 176篇 |
2000年 | 152篇 |
1999年 | 144篇 |
1998年 | 119篇 |
1997年 | 98篇 |
1996年 | 125篇 |
1995年 | 107篇 |
1994年 | 92篇 |
1993年 | 65篇 |
1992年 | 61篇 |
1991年 | 47篇 |
1990年 | 32篇 |
1989年 | 22篇 |
1988年 | 18篇 |
1987年 | 22篇 |
1986年 | 14篇 |
1985年 | 17篇 |
1984年 | 2篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 6篇 |
1980年 | 8篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 6篇 |
1974年 | 4篇 |
1973年 | 3篇 |
排序方式: 共有9605条查询结果,搜索用时 31 毫秒
51.
Dr. Zhenghai Yang Dr. Srinivas Doddipatla Dr. Chao He Vladislav S. Krasnoukhov Prof. Dr. Valeriy N. Azyazov Prof. Dr. Alexander M. Mebel Prof. Dr. Ralf I. Kaiser 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(60):13584-13589
The silene molecule (H2SiCH2; X1A1) has been synthesized under single collision conditions via the bimolecular gas phase reaction of ground state methylidyne radicals (CH) with silane (SiH4). Exploiting crossed molecular beams experiments augmented by high-level electronic structure calculations, the elementary reaction commenced on the doublet surface through a barrierless insertion of the methylidyne radical into a silicon-hydrogen bond forming the silylmethyl (CH2SiH3; X2A′) complex followed by hydrogen migration to the methylsilyl radical (SiH2CH3; X2A′). Both silylmethyl and methylsilyl intermediates undergo unimolecular hydrogen loss to silene (H2SiCH2; X1A1). The exploration of the elementary reaction of methylidyne with silane delivers a unique view at the widely uncharted reaction dynamics and isomerization processes of the carbon–silicon system in the gas phase, which are noticeably different from those of the isovalent carbon system thus contributing to our knowledge on carbon silicon bond couplings at the molecular level. 相似文献
52.
Prof. Yukishige Ito Prof. Yasuhiro Kajihara Prof. Yoichi Takeda 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(67):15461-15470
The introduction of Asn-linked glycans to nascent polypeptides occurs in the lumen of the endoplasmic reticulum of eukaryotic cells. After the removal of specific sugar residues, glycoproteins acquire signals in the glycoprotein quality control (GPQC) system and enter the folding cycle composed of lectin-chaperones calnexin (CNX) and calreticulin (CRT), glucosidase II (G-II), and UDP-Glc:glycoprotein glucosyltransferase (UGGT). G-II initiates glycoproteins’ entry and exit from the cycle, and UGGT serves as the “folding sensor”. This account summarizes our effort to analyze the properties of enzymes and lectins that play important roles in GPQC, especially those involved in the CNX/CRT cycle. To commence our study, general methods for the synthesis of high-mannose-type glycans and glycoproteins were established. Based on these, various substrates to analyze components of the GPQC were created, and properties of CRT, G-II, and UGGT have been clarified. 相似文献
53.
Prof. Dr. Peter Hess 《Chemphyschem》2022,23(6):e202100880
In the periodic table the position of each atom follows the ‘aufbau’ principle of the individual electron shells. The resulting intrinsic periodicity of atomic properties determines the overall behavior of atoms in two-dimensional (2D) bonding and structure formation. Insight into the type and strength of bonding is the key in the discovery of innovative 2D materials. The primary features of 2D bonding and the ensuing monolayer structures of the main-group II–VI elements result from the number of valence electrons and the change of atom size, which determine the type of hybridization. The results reveal the tight connection between strength of bonding and bond length in 2D networks. The predictive power of the periodic table reveals general rules of bonding, the bonding-structure relationship, and allows an assessment of published data of 2D materials. 相似文献
54.
Vinod K. Ahirrao Rajiv A. Jadhav Suyog N. Vaidya Sachin S. Bhagwat Ravindra D. Yeole Mahesh V. Patel 《Biomedical chromatography : BMC》2022,36(6):e5354
Antibiotic susceptibility test (AST) discs are used as an in-vitro diagnostic tool to select the appropriate antibiotic to treat an infection. Generally, the concentration of the drug loaded on to the AST discs is measured by studying its activity against quality control organisms. This methodology has several limitations—it is time consuming, requires trained manpower, has a wider acceptance criteria of zone of inhibitions—causing ambiguity in judging smaller variations in drug concentration. To overcome these issues, we have developed and validated high-performance liquid chromatographic (HPLC) methods for the determination of strength of AST discs for in-house researched antibiotics, namely Levonadifloxacin/WCK 771, Nafithromycin/WCK 4873, Cefepime-Tazobactam/WCK 4282, and Cefepime-Zidebactam/WCK 5222. The drugs were extracted from the AST discs using an appropriate solvent. The developed methods are simple, accurate, precise, reproducible, rugged, and robust. They are efficient in terms of time, and can be easily conducted in a quality control laboratory during release as well as stability evaluation of AST disc. Application of HPLC methods for the determination of strength of AST discs ensures flawless quality and, consequently, a better selection of drugs to treat bacterial infections in clinics. 相似文献
55.
Dr. Joseph N. Capilato Stefan A. Harry Dr. Maxime A. Siegler Prof. Thomas Lectka 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(8):e202103922
As appreciation for nonclassical hydrogen bonds has progressively increased, so have efforts to characterize these interesting interactions. Whereas several kinds of C−H hydrogen bonds have been well-studied, much less is known about the R3N+−C−H⋅⋅⋅X variety. Herein, we present crystallographic and spectroscopic evidence for the existence of these interactions, with special relevance to Selectfluor chemistry. Of particular note is the propensity for Lewis bases to engage in nonclassical hydrogen bonding over halogen bonding with the electrophilic F atom of Selectfluor. Further, the first examples of 1H NMR experiments detailing R3N+−C−H⋅⋅⋅X (X=O, N) hydrogen bonds are described. 相似文献
56.
Chikako Matsuda Ryo Igarashi Prof. Dr. Hiroshi Katagiri Dr. Takashi Murase 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(19):e202200132
Tri- and tetra-fluorinated [7]helicenes are photolabile and undergo a double fluorine atom transfer. Herein, we show that the transferred product further undergoes a skeletal transformation on silica gel. The transformation begins with activation of the allylic C−F bond on the silanol surface. Then, the resulting carbocation readily undergoes a regioselective nucleophilic aromatic substitution with water, depending on the position of the fluorine substituents. Hexafluoro-2-propanol also activated the allylic C−F bond and acted as a nucleophile. These findings support the generation of a highly reactive cationic electrophilic intermediate in the successive transformations involving fluorine atoms. 相似文献
57.
Influence of staff number and internal constellation on surgical site infection in an operating room
Prediction of bacteria-carrying particle (BCP) dispersion and particle distribution released from staffmem- bers in an operating room (OR) is very important for creating and sustaining a safe indoor environment. Postoperative wound infections cause significant morbidity and mortality, and contribute to increased hospitalization time. Increasing the number of personnel within the OR disrupts the ventilation airflow pattern and causes enhanced contamination risk in the area of an open wound. Whether the amount of staffwithin the OR influences the BCP distribution in the surgical zone has rarely been investigated. This study was conducted to explore the influence of the number of personnel in the OR on the airflow field and the BCP distribution. This was performed by applying a numerical calculation to map the airflow field and Lagrangian particle tracking (LPT) for the BCP phase. The results are reported both for active sampling and passive monitoring approaches. Not surprisingly, a growing trend in the BCP concentration (cfu/ms) was observed as the amount of staff in the OR increased. Passive sampling shows unpredictable results due to the sedimentation rate, especially for small particles (5-10 i~m). Risk factors for surgical site infections (SSls) must be well understood to develop more effective prevention programs. 相似文献
58.
A novel strategy for the construction of many-electron symmetry-adapted wave function is proposed for ab initio valence bond (VB) calculations and is implemented for valence bond self-consistent filed (VBSCF) and breathing orbital valence bond (BOVB) methods with various orbital optimization algorithms. Symmetry-adapted VB functions are constructed by the projection operator of symmetry group. The many-electron symmetry-adapted wave function is expressed in terms of symmetry-adapted VB functions, and thus the VB calculations can be performed with the molecular symmetry restriction. Test results show that molecular symmetry reduces the computational cost of both the iteration numbers and CPU time. Furthermore, excited states with specific symmetry can be conveniently obtained in VB calculations by using symmetry-adapted VB functions. 相似文献
59.
The excited-state dynamics of the excited-state proton transfer and intramolecular twisted charge transfer (TICT) reactions of a molecular photoswitch 2-(4′-diethylamino-2′-hydroxyphenyl)-1H-imidazo-[4,5-b]pyridine (DHP) in aprotic and alcoholic solvents have been theoretically investigated by using time-dependent density functional theory. The excited-state intramolecular proton transfer (ESIPT) reaction of DHP proceeding upon excitation in all the solvents has been confirmed, and the dual emission has been assigned to the enol and keto forms of DHP. However, for methanol and ethanol solvents within strong hydrogen-bonded capacity, the intermolecular hydrogen bonds between DHP and methanol/ethanol would promote an excited-state double proton transfer (ESDPT) along the hydrogen-bonded bridge. Importantly, the previous proposed ESDPT-triggered TICT mechanism of DHP in methanol and ethanol was not supported by our calculations. The twist motion would increase the total energy of the system for both the products of ESIPT and ESDPT. According to the calculations of the transition states, the ESDPT reaction occurs much easier in keto form generated by ESIPT. Therefore, a sequential ESIPT and ESDPT mechanism of DHP in methanol and ethanol has been reasonably proposed. 相似文献
60.
Kangkan Sarmah Amlan J. Kalita Ankur K. Guha 《International journal of quantum chemistry》2023,123(1):e27006
Attachment of one electron to 1,2-diBeX-benzene and 1,2-diZnX-benzene derivatives leads to the formation of stronger Be Be and Zn Zn interaction compared to the neutral one. This is reflected in the dramatic shortening of the Be Be and Zn Zn distance. The formation of these 2-center-1-electron bonds have also been confirmed by topological survey of electron density using quantum theory of atoms in molecules and electron localization function. The formation of these bonds is expected to render stability to these radical anions. These radical anions are stable toward electron detachment and computed bond dissociation energy values are also significant. 相似文献